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Invitrogen
IL-6R Polyclonal Antibody
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FIGURE: 1 / 4
IL-6R Antibody (PA5-102425) in IHC (P)
Immunohistochemistry analysis of IL-6R in human pancreatic cancer and adjacent normal tissues. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with IL-6R polyclonal antibody (Product # PA5-102425) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-102425
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IL6R(Accession P08887), corresponding to amino acid residues L45-S95.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IL6R.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; ILN; Interleukin; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991; unnamed protein product
Gene Aliases: CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6R; IL6RA; IL6RQ
UniProt ID: (Human) P08887, (Mouse) P22272
Entrez Gene ID: (Human) 3570, (Mouse) 16194
cytokine receptor activity
ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
interleukin-6 receptor binding
protein binding
enzyme binding
interleukin-11 binding
interleukin-6 binding
protein homodimerization activity
ciliary neurotrophic factor binding
transmembrane signal receptor
hepatic immune response
neutrophil mediated immunity
monocyte chemotaxis
positive regulation of leukocyte chemotaxis
acute-phase response
JAK-STAT cascade
positive regulation of cell proliferation
vascular endothelial growth factor production
cytokine-mediated signaling pathway
endocrine pancreas development
developmental process
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of interleukin-6 production
negative regulation of collagen biosynthetic process
response to cytokine
interleukin-11-mediated signaling pathway
positive regulation of MAPK cascade
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
positive regulation of glomerular mesangial cell proliferation
T-helper 17 cell lineage commitment
extrinsic apoptotic signaling pathway
receptor signaling pathway via STAT
positive regulation of platelet aggregation
positive regulation of activation of Janus kinase activity
cell growth
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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