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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Highly purified (>98% pure) recombinant human endothelial IL-8 (77 amino acid residues).|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 3 publications below|
|Immunohistochemistry (Frozen) (IHC (F))||See 1 publications below|
|Immunohistochemistry (Paraffin, Frozen) (IHC (P, F))||See 3 publications below|
|ELISA (ELISA)||See 1 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
Interleukin 8 is a pro-inflammatory factor which belongs to the CXC subfamily of chemokinesk, and which are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and is a potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Validation and clinicopathologic associations of a urine-based bladder cancer biomarker signature.
AHC0881 was used in immunohistochemistry - paraffin section to validate the expression of a urine-based bladder cancer associated diagnostic signature
|Zhang G,Gomes-Giacoia E,Dai Y,Lawton A,Miyake M,Furuya H,Goodison S,Rosser CJ||Diagnostic pathology (9:null)||2015|
The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma.
AHC0881 was used in immunohistochemistry - paraffin section and western blot to study the expression and role of CXCR2 and SOCS3 in renal cell carcinoma aggresiveness and metastasis
|Stofas A,Levidou G,Piperi C,Adamopoulos C,Dalagiorgou G,Bamias A,Karadimou A,Lainakis GA,Papadoukakis S,Stravodimos K,Dimopoulos MA,Patsouris E,Gakiopoulou H,Korkolopoulou P||BMC cancer (14:null)||2014|
Interleukin-8, a promising predictor for prognosis of pancreatic cancer.
AHC0881 was used in immunohistochemistry - paraffin section to assess IL-8 as a biomarker for prognosis of pancreatic cancer.
|Chen Y,Shi M,Yu GZ,Qin XR,Jin G,Chen P,Zhu MH||World journal of gastroenterology (18:1123)||2012|
Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa.
AHC0881 was used in immunohistochemistry - frozen section to investigate the cause of follicular occlusion.
|Emelianov VU,Bechara FG,Gläser R,Langan EA,Taungjaruwinai WM,Schröder JM,Meyer KC,Paus R||The British journal of dermatology (166:1023)||2012|
|Mouse||Not Cited||Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis.||Shahzad MM,Arevalo JM,Armaiz-Pena GN,Lu C,Stone RL,Moreno-Smith M,Nishimura M,Lee JW,Jennings NB,Bottsford-Miller J,Vivas-Mejia P,Lutgendorf SK,Lopez-Berestein G,Bar-Eli M,Cole SW,Sood AK||The Journal of biological chemistry (285:35462)||2010|
|Human||Not Cited||Clinical and biological significance of vascular endothelial growth factor in endometrial cancer.||Kamat AA,Merritt WM,Coffey D,Lin YG,Patel PR,Broaddus R,Nugent E,Han LY,Landen CN,Spannuth WA,Lu C,Coleman RL,Gershenson DM,Sood AK||Clinical cancer research : an official journal of the American Association for Cancer Research (13:7487)||2007|
|Mouse||Not Cited||Modulation of bone microenvironment with zoledronate enhances the therapeutic effects of STI571 and paclitaxel against experimental bone metastasis of human prostate cancer.||Kim SJ,Uehara H,Yazici S,He J,Langley RR,Mathew P,Fan D,Fidler IJ||Cancer research (65:3707)||2005|
|Human||Not Cited||Specific C-terminal cleavage and inactivation of interleukin-8 by invasive disease isolates of Streptococcus pyogenes.||Edwards RJ,Taylor GW,Ferguson M,Murray S,Rendell N,Wrigley A,Bai Z,Boyle J,Finney SJ,Jones A,Russell HH,Turner C,Cohen J,Faulkner L,Sriskandan S||The Journal of infectious diseases (192:783)||2005|
|Human||Not Cited||Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer.||Huang J,Yao JL,Zhang L,Bourne PA,Quinn AM,di Sant'Agnese PA,Reeder JE||The American journal of pathology (166:1807)||2005|
alveolar macrophage chemotactic factor I; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; chemokine (C-X-C motif) ligand 8; CXCL8; emoctakin; GCP-1; GCP1; granulocyte chemotactic protein 1; interleukin 8; LECT; LUCT; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; LYNAP; MDNCF; MONAP; monocyte-derived neutrophil chemotactic factor; monocyte-derived neutrophil-activating peptide; NAF; NAP-1; neutrophil-activating peptide 1; small inducible cytokine subfamily B, member 8; T-cell chemotactic factor; tumor necrosis factor-induced gene 1
CXCL8; GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1