Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene.
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Protein Aliases: alpha; Enhancer trap locus homolog 2; Etl-2; IL 11 receptor subunit alpha; IL 11R alpha; IL 11R subunit alpha; IL 11RA; IL-11 receptor subunit alpha; IL-11 receptor subunit alpha-1; IL-11R subunit alpha; IL-11R subunit alpha-1; IL-11R-alpha; IL-11R-alpha-1; IL-11RA; Il-11ra-alpha; IL-11RA1; IL11RA; interleukin 11 receptor; interleukin 11 receptor, alpha; interleukin 11 receptor, alpha chain 2; interleukin-11 receptor alpha chain; Interleukin-11 receptor subunit alpha; Interleukin-11 receptor subunit alpha-1; locus 2; Novel cytokine receptor 1; NR-1
Gene Aliases: AI314697; CRSDA; Etl2; GP130; Il-11ra; IL11RA; Il11ra1; Il11ra2; NR1