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Invitrogen
IL12RB1 Polyclonal Antibody
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FIGURE: 1 / 2
IL12RB1 Antibody (PA5-80717) in WB
Western Blot using IL12RB1 Polyclonal Antibody (Product # PA5-80717) at 1:500 dilution. Lane A: A431 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 73 kDa. Observed band size: 64 kDa.
Product Details
PA5-80717
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to the C-terminus of the Human IL12RB1/CD212
Conjugate
Form
Liquid
Concentration
0.97 mg/mL
Amount
97 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human IL12RB1/CD212.
Target Information
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12RB1; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; Interleukin-12 receptor subunit beta-1; MGC34454; unnamed protein product
Gene Aliases: CD212; IL-12R-BETA1; IL12R; IL12RB; IL12RB1; IMD30
UniProt ID: (Human) P42701
Entrez Gene ID: (Human) 3594
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
signal transduction
cell surface receptor signaling pathway
positive regulation of cell proliferation
cytokine-mediated signaling pathway
positive regulation of interferon-gamma production
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
T-helper 1 cell differentiation
cellular response to interferon-gamma
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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