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Invitrogen
IL12RB1 Polyclonal Antibody
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FIGURE: 1 / 1
IL12RB1 Antibody (PA5-95976) in WB
Western blot analysis of IL12RB1 in extracts of various cell lines. Samples were incubated with IL12RB1 Polyclonal antibody (Product # PA5-95976) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5 min.
Product Details
PA5-95976
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_7149121)
Conjugate
Form
Liquid
Concentration
1.63 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RTSECCFQDP PYPDADSGSA SGPRDLRCYR ISSDRYECSW QYEGPTAGVS HFLRCCLSSG RCCYFAAGSA TRLQFSDQAG VSVLYTVTLW VESWARNQTE KSPEVTLQLY NSVKYEPPLG DIKVSKLAGQ LRMEWETPDN QVGAEVQFRH RTPSSPWKLG DCGPQDDDTE SCLCPLEMNV AQEFQLRRRQ LGSQGSSWSK WSSPVCVPPE NPPQPQVRFS VEQLGQDGRR RLTLKEQPTQ LELPEGCQGL APGTEVTYRL QLHMLSCPCK AKATRTLHLG K; Positive Samples: A-431, MCF7, Mouse liver, Mouse thymus; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD212; cluster of differentiation 212; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component); Interleukin-12 receptor subunit beta-1; MGC34454
Gene Aliases: CD212; IL-12R-BETA1; IL-12R[b]; IL12R; IL12RB; IL12RB1; IMD30
UniProt ID: (Human) P42701, (Mouse) Q60837
Entrez Gene ID: (Human) 3594, (Mouse) 16161
positive regulation of T cell mediated cytotoxicity
positive regulation of defense response to virus by host
positive regulation of T-helper 1 type immune response
signal transduction
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
positive regulation of interferon-gamma production
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of activated T cell proliferation
positive regulation of memory T cell differentiation
cellular response to interferon-gamma
positive regulation of T-helper 17 type immune response
positive regulation of T-helper 17 cell lineage commitment
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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