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Product Details
BS-2604R
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide derived from human IL-12RB2, amino acids 301-400. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 50% glycerol, 1% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
-20°C |
Target Information
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-12 receptor subunit beta-2; IL-12R subunit beta-2; IL-12R-beta-2; interferon response to microorganisms; interleukin 12 receptor, beta 2; interleukin-12 receptor beta-2 chain; Interleukin-12 receptor subunit beta-2; RP11-102M16.1
Gene Aliases: A930027I18Rik; Ifnm; IL-12RB2; IL12RB2
UniProt ID: (Human) Q99665, (Mouse) P97378
Entrez Gene ID: (Human) 3595, (Rat) 171334, (Mouse) 16162
Molecular Function:
transmembrane signal receptor
cell surface receptor signaling pathway
positive regulation of cell proliferation
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
response to lipopolysaccharide
interferon-gamma production
positive regulation of interferon-gamma production
response to cytokine
regulation of T-helper cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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