Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
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Protein Aliases: CD217; CDw217; IL-17 receptor A; IL-17RA; Interleukin-17 receptor A; MGC10262
Gene Aliases: AW538159; CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA; VDw217