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Invitrogen
IL17RA Recombinant Rabbit Monoclonal Antibody (R004)
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IL17RA Antibody (MA5-35998) in Flow
Flow Cytometry analysis of IL17RA in human whole blood granulocytes. Cells were stained with IL17RA Recombinant Monoclonal Antibody (Product # MA5-35998), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.
Product Details
MA5-35998
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
R004
Immunogen
Recombinant Human IL-17R/IL-17RA/CD217 Protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
arginine/histidine with 0.02% Tween 80, 120mM NaCl
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F. IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD127; CD217; CDw217; IL-17 receptor A; Interleukin-17 receptor A; MGC10262
Gene Aliases: CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R; IL17RA
UniProt ID: (Human) Q96F46
Entrez Gene ID: (Human) 23765
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
positive regulation of interleukin-23 production
defense response to fungus
granulocyte chemotaxis
fibroblast activation
positive regulation of cytokine production involved in inflammatory response
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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