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Invitrogen
IL17RC Isoform 1 Precursor Polyclonal Antibody
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FIGURE: 1 / 2
IL17RC Isoform 1 Precursor Antibody (PA5-102004) in ICC/IF
Immunocytochemistry analysis of IL17RC Isoform 1 Precursor in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with IL17RC Isoform 1 Precursor polyclonal antibody (Product # PA5-102004) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red)... View More
Product Details
PA5-102004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IL17RC(Accession Q8NAC3), corresponding to amino acid residues L717-F767.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IL17RC.
Target Information
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; Interleukin-17 receptor C; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14
Gene Aliases: CANDF9; IL17-RL; IL17RC; IL17RL; UNQ6118/PRO20040/PRO38901
UniProt ID: (Human) Q8NAC3
Entrez Gene ID: (Human) 84818
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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