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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||17 amino acid peptide near the carboxy terminus of human IL-1F10|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A recommended positive control is human liver tissue lysate.
Two isoforms of IL-1F10 exist.
The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection. IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil. IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses. IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
family of interleukin 1-theta; FIL1 theta; FIL1-theta; FIL1T; FKSG75; IL-1 theta; IL-1F10 (canonical form IL-1F10a); IL-1HY2; IL-38; IL1-theta; IL1HY2; IL38; interleukin 1 family, member 10 (theta); interleukin-1 HY2; interleukin-1 receptor antagonist FKSG75; interleukin-1 receptor antagonist-like FIL1 theta; interleukin-38; UNQ6119/PRO20041
FIL1-theta; FIL1T; FKSG75; IL-1HY2; IL-38; IL1-theta; IL1F10; IL1HY2; IL38; UNQ6119/PRO20041