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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||16 amino acid peptide near the center of human IL-1RL2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||20 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay-Dependent|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A recommended positive control is human small intestine tissue lysate.
At least three isoforms of IL-1RL2 are known to exist; this antibody will detect all three isoforms. IL-1RL2 antibody is not expected to cross-react with IL-1R or IL-1RL1.
IL-1RL2 is a member of the interleukin 1 receptor family, but it is incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. Together with IL-1RAcP, it can bind members of the IL-36 cytokine family, leading to activation of the NF-kappaB pathway. IL-1RL2 can also bind to IL-1F10, resulting in a decreased product of Th17 cytokines in response to immunological or LPS challenge, suggesting that one potential role of IL-1RL2 may be to modulate the immune and inflammation response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
IL-1 receptor-related protein 2; IL-1Rrp2; IL-36 receptor; IL-36R; IL1R-rp2; IL1RRP2; interleukin 1 receptor-like 2; interleukin-1 receptor related protein 2; interleukin-1 receptor-like 2; interleukin-1 receptor-related protein 2
AI481289; AW551444; IL-1Rrp2; IL-36R; IL1R-rp2; IL1RL2; IL1RRP2