In Western blot applications, this antibody detects a band at ~60kDa. A suggested positive control is Raji cell lysate.
PA5-19982 can be used with blocking peptide PEP-0106.
A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor -gamma chain, -gammac, and mediates IL-21 signaling. Both IL-21R and the -gammac are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
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Protein Aliases: CD360; IL-21 receptor; IL-21R; Interleukin-21 receptor; LR-beta; Lymphocyte receptor beta; Novel cytokine receptor 8; Novel interleukin receptor; NR8; UNQ3121/PRO10273, CD360, NILR
Gene Aliases: CD360; IL21R; NILR; UNQ3121/PRO10273