In Western blot applications, this antibody detects a band at ~60kDa. A suggested positive control is Raji cell lysate.
PA5-19983 can be used with blocking peptide PEP-0107.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
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Protein Aliases: CD360; IL-21 receptor; IL-21R; Interleukin-21 receptor; LR-beta; Lymphocyte receptor beta; MGC10967; Novel cytokine receptor 8; Novel interleukin receptor; NR8
Gene Aliases: CD360; IL21R; NILR; UNQ3121/PRO10273
Molecular Function: transmembrane signal receptor