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Proteintech
IL22RA1 Polyclonal Antibody
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Product Details
13462-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IL22RA1 Fusion Protein Ag4056 (253-574 aa encoded by BC029273)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YVTKPPAPP NSLNVQRVLT FQPLRFIQEH VLIPVFDLSG PSSLAQPVQY SQIRVSGPRE PAGAPQRHSL SEITYLGQPD ISILQPSNVP PPQILSPLSY APNAAPEVGP PSYAPQVTPE AQFPFYAPQA ISKVQPSSYA PQATPDSWPP SYGVCMEGSG KDSPTGTLSS PKHLRPKGQL QKEPPAGSCM LGGLSLQEVT SLAMEESQEA KSLHQPLGIC TDRTSDPNVL HSGEEGTPQY LKGQLPLLSS VQIEGHPMSL PLQPPSRPCS PSDQGPSPWG LLESLVCPKD EAKSPAPETS DLEQPTELDS LFRGLALTVQ WES (253-574 aa encoded by BC029273)
Target Information
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CRF2-9; cytokine receptor; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; Interleukin-22 receptor subunit alpha-1; unnamed protein product; ZcytoR11
Gene Aliases: 9130219A07Rik; CRF2-9; ENSMUSG00000073746; IL-22R; IL22R; IL22R1; IL22RA1; RGD1559655
UniProt ID: (Human) Q8N6P7, (Mouse) Q80XZ4
Entrez Gene ID: (Human) 58985, (Mouse) 230828, (Rat) 362629
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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