The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
IL-23R is a 629 aa, novel subunit of the receptor for cytokine IL23A/IL23 which pairs with the receptor molecule IL12RB1/IL12R beta 1and thus take part in IL23A signaling. Signal transduction analysis confirms that this protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. Alternative splicing results in six spliced isoforms of IL-23R. Reports suggest that IL-23R plays an important role in psoriasis pathogenesis and is also a potential therapeutic target in inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IBD17; IL 23R; IL-23 receptor; interleukin 23 receptor; interleukin 23 receptor-like; Interleukin-23 receptor
Gene Aliases: IL-23R; IL23R
Molecular Function: transmembrane signal receptor