In Western blots, approximately 5% cross-reactivity with recombinant human (rh) IL-2 R gamma is observed and less than 1% cross-reactivity with rhIL-2 R alpha, recombinant mouse IL-2 R beta, and rhIL-15 R is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
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Protein Aliases: CD132; CD132 antigen; CIDX; Cytokine receptor common subunit gamma; gamma (c); gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2R gamma; IL2RG; IMD4; Interleukin-2 receptor subunit gamma; P64; SCIDX; SCIDX1
Gene Aliases: [g]c; CD132; gamma(c); gc; Il2rg; p64
UniProt ID: (Mouse) P34902
Entrez Gene ID: (Mouse) 16186