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Product Details
PA5-119229
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Interleukin 31 Receptor A. The antigen corresponds to amino acid range 205-456 of the target protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903727
Target Information
IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: class I cytokine receptor; CRL 3; CRL3Glmr; Cytokine receptor-like 3; GLM R; GLM-R; GLM-RMGC125346; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; HGLM R; hGLM-R; HGLMR; IL 31RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31RAGPLCRL; IL31R subunit alpha; Interleukin-31 receptor subunit alpha; MGC125346; PLCA 2; soluble type I cytokine receptor CRL3; ZcytoR17
Gene Aliases: CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R; IL-31RA; IL31RA; PLCA2; PRO21384; UNQ6368/PRO21073/PRO21384
UniProt ID: (Human) Q8NI17
Entrez Gene ID: (Human) 133396
MAPK cascade
glandular epithelial cell differentiation
acute inflammatory response to antigenic stimulus
defense response
transmembrane receptor protein tyrosine kinase signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
monocyte differentiation
macrophage differentiation
T-helper 2 cell cytokine production
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
homeostatic process
negative regulation of macrophage activation
negative regulation of apoptotic process
positive regulation of transcription, DNA-templated
defense response to other organism
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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