Immunogen sequence: VMAKHSSVYP TQEELEAVQN MVSHTERALK AVSDWIDEQE KGSSEQAESD NMDVPPEDDS KEGAGEQKTE HMTRTLRGVM RVGLVAKGLL LKGDLDLELV LLCKEKPTTA LLDKVADNLA IQLAAVTEDK YEILQSVDDA AIVIK
UBA6 (UBE1L2, MOP-4)is a novel E1 enzyme specific for ubiquitin and belongs to the ubiquitin-activating E1 family. It is a part of the cascade to attach ubiquitin (Ub) covalently to substrate proteins. UBA6 activates ubiquitin by first adenylating its carboxy-terminal glycine residue with ATP and then linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Its isoforms influence spermatogenesis and male fertility. UBA6 is highly expressed in human monocytes.
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Protein Aliases: Double-stranded RNA-binding protein 76; double-stranded RNA-binding protein, 76 kD; DRBP76; dsRNA binding protein NFAR-2/MPP4; interleukin enhancer binding factor 3, 90kD; interleukin enhancer binding factor 3, 90kDa; Interleukin enhancer-binding factor 3; M-phase phosphoprotein 4; MPHOSPH4; MPP4; NF-AT-90; NF90; NFAR; NFAR-1; Nuclear factor associated with dsRNA; Nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; TCP80; Translational control protein 80
Gene Aliases: CBTF; DRBF; DRBP76; ILF3; MMP4; MPHOSPH4; MPP4; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b; NFAR; NFAR-1; NFAR2; TCP110; TCP80
UniProt ID: (Human) Q12906
Entrez Gene ID: (Human) 3609