Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK is a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction.
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Protein Aliases: 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; ILK; ILK 1; ILK 2; ILK-1; ILK-2; ILK1; ILK2; integrin binding protein kinase; integrin linked kinase; integrin-linked kinase; integrin-linked kinase-2; Integrin-linked protein kinase; loc; lost-contact; main squeeze; msq; P59; p59ILK; zilk
Gene Aliases: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK; zgc:65842