Immunogen sequence: MDDIFTQCR EGNAVAVRLW LDNTENDLNQ GDDHGFSPLH WACREGRSAV VEMLIMRGAR INVMNRGDDT PLHLAASHGH RDIVQKLLQY KADINAVNEH GNVPLHYACF WGQDQVAEDL VANGALVSIC NKYGEMPVDK AKAPLRELLR ERAEKMGQNL NRIPYKDTFW KGTTRTRPRN GTLNKHSGID FKQLNFLTKL NENHSGELWK GRWQGNDIVV KVLKVRDWST RKSRDFNEEC PRLRIFSHPN VLPVLGACQS PPAPHPTLIT HWMPYGSLYN VLHEGTNFVV DQSQAVKFAL DMARGMAFLH TLEPLIPRHA LNSRSVMIDE DMTARISMAD VKFSFQCPGR MYAPAWVAPE ALQKKPEDTN RRSADMWSFA VLLWELVTRE VPFADLSNME IGMKVALEGL RPTIPPGISP HVCKLMKICM NEDPAKRPKF DMIVPILEKM QDK (1-452 aa encoded by BC001554)
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
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Protein Aliases: 59 kDa serine/threonine-protein kinase; Beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK-1; ILK-2; integrin binding protein kinase; Integrin linked ILK; integrin-linked kinase; integrin-linked kinase-2; Integrin-linked protein kinase; p59ILK
Gene Aliases: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK
Molecular Function: non-receptor serine/threonine protein kinase