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Proteintech

ILK Polyclonal Antibody

1 Reference
View all (31) ILK antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

24926-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:20-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ILK Fusion Protein Ag21494 (1-452 aa encoded by BC001554)
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MDDIFTQCR EGNAVAVRLW LDNTENDLNQ GDDHGFSPLH WACREGRSAV VEMLIMRGAR INVMNRGDDT PLHLAASHGH RDIVQKLLQY KADINAVNEH GNVPLHYACF WGQDQVAEDL VANGALVSIC NKYGEMPVDK AKAPLRELLR ERAEKMGQNL NRIPYKDTFW KGTTRTRPRN GTLNKHSGID FKQLNFLTKL NENHSGELWK GRWQGNDIVV KVLKVRDWST RKSRDFNEEC PRLRIFSHPN VLPVLGACQS PPAPHPTLIT HWMPYGSLYN VLHEGTNFVV DQSQAVKFAL DMARGMAFLH TLEPLIPRHA LNSRSVMIDE DMTARISMAD VKFSFQCPGR MYAPAWVAPE ALQKKPEDTN RRSADMWSFA VLLWELVTRE VPFADLSNME IGMKVALEGL RPTIPPGISP HVCKLMKICM NEDPAKRPKF DMIVPILEKM QDK (1-452 aa encoded by BC001554)

Target Information

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 59 kDa serine/threonine-protein kinase; Beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK-1; ILK-2; integrin binding protein kinase; Integrin linked ILK; integrin-linked kinase; integrin-linked kinase-2; Integrin-linked protein kinase; p59ILK

Gene Aliases: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK

UniProt ID: (Human) Q13418, (Mouse) O55222

Entrez Gene ID: (Human) 3611, (Mouse) 16202

Molecular Function: non-receptor serine/threonine protein kinase

Function(s)
branching involved in ureteric bud morphogenesis positive regulation of cell-matrix adhesion outflow tract morphogenesis protein phosphorylation negative regulation of protein kinase activity cell cycle arrest cell-matrix adhesion integrin-mediated signaling pathway cell aging cell proliferation positive regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process fibroblast migration negative regulation of smooth muscle cell migration peptidyl-serine phosphorylation nerve development myelination in peripheral nervous system positive regulation of cell migration positive regulation of BMP signaling pathway myelin assembly regulation of actin cytoskeleton organization cell junction assembly substrate adhesion-dependent cell spreading positive regulation of phosphorylation extracellular fibril organization positive regulation of MAP kinase activity protein kinase B signaling negative regulation of neuron apoptotic process establishment or maintenance of epithelial cell apical/basal polarity positive regulation of myoblast differentiation positive regulation of osteoblast differentiation positive regulation of axon extension positive regulation of transcription, DNA-templated negative regulation of smooth muscle cell proliferation neuron projection morphogenesis positive regulation of dendrite morphogenesis protein heterooligomerization positive regulation of protein kinase B signaling platelet aggregation positive regulation of canonical Wnt signaling pathway negative regulation of neural precursor cell proliferation regulation of cell growth regulation of signal transduction Schwann cell development phosphorylation cell projection organization negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of axonogenesis
Process(es)
protein serine/threonine kinase activity signal transducer activity integrin binding protein binding ATP binding SH3 domain binding protein kinase binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
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