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Bethyl Laboratories
ILK Polyclonal Antibody
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FIGURE: 1 / 1
ILK Antibody (IHC-00361) in ICC/IF
Detection of human ILK by immunocytochemistry. Sample: Acetone-fixed asynchronous HeLa cells. Antibody: Affinity purified rabbit anti-ILK (Product # IHC-00361) used at a dilution of 1:250. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus™ 555 used at a dilution of 1:100.
Product Details
IHC-00361
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 402 and 451 of human integrin-linked kinase.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Zebrafish, Chicken, Sheep, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey and Gorilla
Target Information
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 59 kDa serine/threonine-protein kinase; beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK; ILK-1; ILK-2; Inactive integrin-linked kinase; Integrin linked ILK; integrin-linked kinase-2; p59ILK; Scaffold protein ILK; unnamed protein product
Gene Aliases: HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK
UniProt ID: (Human) Q13418
Entrez Gene ID: (Human) 3611
cell morphogenesis
branching involved in ureteric bud morphogenesis
outflow tract morphogenesis
mitotic spindle organization
cell-matrix adhesion
integrin-mediated signaling pathway
cell proliferation
positive regulation of cell proliferation
anatomical structure morphogenesis
positive regulation of signal transduction
fibroblast migration
Schwann cell development
nerve development
myelination in peripheral nervous system
cell projection organization
cell differentiation
positive regulation of BMP signaling pathway
tumor necrosis factor-mediated signaling pathway
substrate adhesion-dependent cell spreading
positive regulation of I-kappaB kinase/NF-kappaB signaling
protein kinase B signaling
establishment or maintenance of epithelial cell apical/basal polarity
positive regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
neural precursor cell proliferation
platelet aggregation
caveola assembly
protein localization to cell cortex
positive regulation of canonical Wnt signaling pathway
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of neural precursor cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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