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Product Details
16593-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IMPA1 Fusion Protein Ag9632 (1-277 aa encoded by BC008381)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MADPWQECM DYAVTLARQA GEVVCEAIKN EMNVMLKSSP VDLVTATDQK VEKMLISSIK EKYPSHSFIG EESVAAGEKS ILTDNPTWII DPIDGTTNFV HRFPFVAVSI GFAVNKKIEF GVVYSCVEGK MYTARKGKGA FCNGQKLQVS QQEDITKSLL VTELGSSRTP ETVRMVLSNM EKLFCIPVHG IRSVGTAAVN MCLVATGGAD AYYEMGIHCW DVAGAGIIVT EAGGVLMDVT GGPFDLMSRR VIAANNRILA ERIAKEIQVI PLQRDDED (1-277 aa encoded by BC008381)
Target Information
IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1; testicular tissue protein Li 94
Gene Aliases: 2610002K09Rik; 2900059K10Rik; AI325909; IMP; IMPA; IMPA1; Impa1-L
UniProt ID: (Human) P29218, (Rat) P97697
Entrez Gene ID: (Human) 3612, (Rat) 83523, (Mouse) 55980
magnesium ion binding
protein binding
inositol monophosphate 1-phosphatase activity
manganese ion binding
lithium ion binding
identical protein binding
protein homodimerization activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
hydrolase activity
metal ion binding
phosphatase
inositol metabolic process
inositol biosynthetic process
phosphatidylinositol biosynthetic process
phosphate-containing compound metabolic process
signal transduction
inositol phosphate metabolic process
phosphatidylinositol phosphorylation
inositol phosphate dephosphorylation
response to lithium ion
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