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Invitrogen
INAVA Polyclonal Antibody
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Product Details
PA5-55635
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human C1orf106. Recombinant protein control fragment (Product #RP-94427).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPQTLEGLQP TGPEAGSPER APVQNSPWKE TSLDHPYEKP RKSSEPWSES SSPATTPQDG PSASSLWLLE PASYHVVPIR G
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
Target Information
Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Innate immunity activator protein; uncharacterized protein C1orf106; unnamed protein product
Gene Aliases: C1orf106; INAVA
UniProt ID: (Human) Q3KP66
Entrez Gene ID: (Human) 55765
pattern recognition receptor signaling pathway
immune system process
positive regulation of cytokine production involved in immune response
positive regulation of protein ubiquitination
response to peptidoglycan
response to muramyl dipeptide
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-6 production
positive regulation of stress-activated MAPK cascade
adherens junction maintenance
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
innate immune response
intestinal epithelial structure maintenance
nucleotide-binding oligomerization domain containing 2 signaling pathway
reactive oxygen species biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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