Proteintech

INF2 Polyclonal Antibody

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Antibody Testing Data (8)

INF2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

INF2 Antibody (20466-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed NIH/3T3 cells using 20466-1-AP (INF2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

INF2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

INF2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

20466-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 15 publications 15 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

INF2 Fusion Protein Ag14302 (733-1082 aa encoded by BC008756)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVRPKAQLV LAACESLLTS RQLPIFCQLI LRIGNFLNYG SHTGDADGFK ISTLLKLTET KSQQNRVTLL HHVLEEAEKS HPDLLQLPRD LEQPSQAAGI NLEIIRSEAS SNLKKLLETE RKVSASVAEV QEQYTERLQA SISAFRALDE LFEAIEQKQR ELADYLCEDA QQLSLEDTFS TMKAFRDLFL RALKENKDRK EQAAKAERRK QQLAEEEARR PRGEDGKPVR KGPGKQEEVC VIDALLADIR KGFQLRKTAR GRGDTDGGSK AASMDPPRAT EPVATSNPAG DPVGSTRCPA SEPGLDATTA SESRGWDLVD AVTPGPQPTL EQLEEGGPRP LERRSSWYVD A (733-1082 aa encoded by BC008756)

Target Information

This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1.

The EMBO journal

Phuyal S,Djaerff E,Le Roux AL,Baker MJ,Fankhauser D,Mahdizadeh SJ,Reiterer V,Parizadeh A,Felder E,Kahlhofer JC,Teis D,Kazanietz MG,Geley S,Eriksson L,Roca-Cusachs P,Farhan H

Thu Sep 15 00:00:00 EDT 2022

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.

Frontiers in cellular neuroscience

González-Barriga A,Lallemant L,Dincã DM,Braz SO,Polvèche H,Magneron P,Pionneau C,Huguet-Lachon A,Claude JB,Chhuon C,Guerrera IC,Bourgeois CF,Auboeuf D,Gourdon G,Gomes-Pereira M

Wed May 26 00:00:00 EDT 2021

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Frontiers in microbiology

Wang B,Zhang C,Yu C,Zhu Y,Tang Q,Huang H,Zhao Z

Sun May 30 00:00:00 EDT 2021

Enterovirus 71 Induces INF2 Cleavage via Activated Caspase-2 in Infected RD Cells.

Frontiers in microbiology

Wang B,Zhang C,Yu C,Zhu Y,Tang Q,Huang H,Zhao Z

Sun May 30 00:00:00 EDT 2021

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.

Journal of the American Society of Nephrology : JASN

Subramanian B,Chun J,Perez-Gill C,Yan P,Stillman IE,Higgs HN,Alper SL,Schlöndorff JS,Pollak MR

Sat Feb 01 00:00:00 EST 2020

Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells.

Developmental cell

Teo JL,Gomez GA,Weeratunga S,Davies EM,Noordstra I,Budnar S,Katsuno-Kambe H,McGrath MJ,Verma S,Tomatis V,Acharya BR,Balasubramaniam L,Templin RM,McMahon KA,Lee YS,Ju RJ,Stebhens SJ,Ladoux B,Mitchell CA,Collins BM,Parton RG,Yap AS

Mon Jul 06 00:00:00 EDT 2020

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Cell reports

Uzureau S,Lecordier L,Uzureau P,Hennig D,Graversen JH,Homblé F,Mfutu PE,Oliveira Arcolino F,Ramos AR,La Rovere RM,Luyten T,Vermeersch M,Tebabi P,Dieu M,Cuypers B,Deborggraeve S,Rabant M,Legendre C,Moestrup SK,Levtchenko E,Bultynck G,Erneux C,Pérez-Morga D,Pays E

Tue Mar 17 00:00:00 EDT 2020

Cytoskeleton regulators CAPZA2 and INF2 associate with CFTR to control its plasma membrane levels under EPAC1 activation.

The Biochemical journal

Santos JD,Pinto FR,Ferreira JF,Amaral MD,Zaccolo M,Farinha CM

Fri Jul 17 00:00:00 EDT 2020

Multiple formin proteins participate in glioblastoma migration.

BMC cancer

Heuser VD,Kiviniemi A,Lehtinen L,Munthe S,Kristensen BW,Posti JP,Sipilä JOT,Vuorinen V,Carpén O,Gardberg M

Wed Jul 29 00:00:00 EDT 2020

Calcium Wave Promotes Cell Extrusion.

Current biology : CB

Takeuchi Y,Narumi R,Akiyama R,Vitiello E,Shirai T,Tanimura N,Kuromiya K,Ishikawa S,Kajita M,Tada M,Haraoka Y,Akieda Y,Ishitani T,Fujioka Y,Ohba Y,Yamada S,Hosokawa Y,Toyama Y,Matsui T,Fujita Y

Mon Feb 24 00:00:00 EST 2020

Calcium Wave Promotes Cell Extrusion.

Current biology : CB

Takeuchi Y,Narumi R,Akiyama R,Vitiello E,Shirai T,Tanimura N,Kuromiya K,Ishikawa S,Kajita M,Tada M,Haraoka Y,Akieda Y,Ishitani T,Fujioka Y,Ohba Y,Yamada S,Hosokawa Y,Toyama Y,Matsui T,Fujita Y

Mon Feb 24 00:00:00 EST 2020

INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen Z,Wang C,Yu N,Si L,Zhu L,Zeng A,Liu Z,Wang X

Fri Mar 01 00:00:00 EST 2019

INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen Z,Wang C,Yu N,Si L,Zhu L,Zeng A,Liu Z,Wang X

Fri Mar 01 00:00:00 EST 2019

Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.

Journal of receptor and signal transduction research

Xie Z,Zhou Y,Duan X,Yang L

Mon Apr 01 00:00:00 EDT 2019

Inhibitory effect of Tanshinone IIA on inverted formin-2 protects HaCaT cells against oxidative injury via regulating mitochondrial stress.

Journal of receptor and signal transduction research

Xie Z,Zhou Y,Duan X,Yang L

Mon Apr 01 00:00:00 EDT 2019

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

American journal of cancer research

Jin X,Wang J,Li Q,Zhuang H,Yang J,Lin Z,Lin T,Lv Z,Shen L,Yan C,Zheng J,Zhu J,Gong Z,Wang C,Gao K

Thu Dec 07 00:00:00 EST 2023

SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer.

American journal of cancer research

Jin X,Wang J,Li Q,Zhuang H,Yang J,Lin Z,Lin T,Lv Z,Shen L,Yan C,Zheng J,Zhu J,Gong Z,Wang C,Gao K

Thu Dec 07 00:00:00 EST 2023

Hic-5 regulates Src-induced invadopodia rosette formation and organization.

Molecular biology of the cell

Gulvady AC,Forsythe IJ,Turner CE

Wed May 15 00:00:00 EDT 2019

Hic-5 regulates Src-induced invadopodia rosette formation and organization.

Molecular biology of the cell

Gulvady AC,Forsythe IJ,Turner CE

Wed May 15 00:00:00 EDT 2019

Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission.

Journal of cellular physiology

Li X,Wu M,An D,Yuan H,Li Z,Song Y,Liu Z

Sun Sep 01 00:00:00 EDT 2019

Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission.

Journal of cellular physiology

Li X,Wu M,An D,Yuan H,Li Z,Song Y,Liu Z

Sun Sep 01 00:00:00 EDT 2019

Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.

American journal of physiology. Cell physiology

Tonsawan P,Dylewski J,Lewis L,Blaine J

Fri Nov 01 00:00:00 EDT 2019

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics.

Nature communications

Wang Y,Sherrard A,Zhao B,Melak M,Trautwein J,Kleinschnitz EM,Tsopoulidis N,Fackler OT,Schwan C,Grosse R

Thu Nov 21 00:00:00 EST 2019

Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.

The international journal of biochemistry & cell biology

Zhang Z,Yu J

Thu Nov 01 00:00:00 EDT 2018

Nurr1 exacerbates cerebral ischemia-reperfusion injury via modulating YAP-INF2-mitochondrial fission pathways.

The international journal of biochemistry & cell biology

Zhang Z,Yu J

Thu Nov 01 00:00:00 EDT 2018

Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.

Journal of molecular histology

Zhao H,Pan W,Chen L,Luo Y,Xu R

Sat Dec 01 00:00:00 EST 2018

Nur77 promotes cerebral ischemia-reperfusion injury via activating INF2-mediated mitochondrial fragmentation.

Journal of molecular histology

Zhao H,Pan W,Chen L,Luo Y,Xu R

Sat Dec 01 00:00:00 EST 2018

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast cancer : basic and clinical research

Heuser VD,Mansuri N,Mogg J,Kurki S,Repo H,Kronqvist P,Carpén O,Gardberg M

Tue Sep 29 00:00:00 EDT 2020

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast cancer : basic and clinical research

Heuser VD,Mansuri N,Mogg J,Kurki S,Repo H,Kronqvist P,Carpén O,Gardberg M

Tue Sep 29 00:00:00 EDT 2020

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast cancer : basic and clinical research

Heuser VD,Mansuri N,Mogg J,Kurki S,Repo H,Kronqvist P,Carpén O,Gardberg M

Tue Sep 29 00:00:00 EDT 2020

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast cancer : basic and clinical research

Heuser VD,Mansuri N,Mogg J,Kurki S,Repo H,Kronqvist P,Carpén O,Gardberg M

Tue Sep 29 00:00:00 EDT 2020

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast cancer : basic and clinical research

Heuser VD,Mansuri N,Mogg J,Kurki S,Repo H,Kronqvist P,Carpén O,Gardberg M

Tue Sep 29 00:00:00 EDT 2020

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.

PLoS genetics

Jin X,Wang J,Gao K,Zhang P,Yao L,Tang Y,Tang L,Ma J,Xiao J,Zhang E,Zhu J,Zhang B,Zhao SM,Li Y,Ren S,Huang H,Yu L,Wang C

Sat Apr 01 00:00:00 EDT 2017

Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.

PLoS genetics

Jin X,Wang J,Gao K,Zhang P,Yao L,Tang Y,Tang L,Ma J,Xiao J,Zhang E,Zhu J,Zhang B,Zhao SM,Li Y,Ren S,Huang H,Yu L,Wang C

Sat Apr 01 00:00:00 EDT 2017

FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.

Cell

Skau CT,Fischer RS,Gurel P,Thiam HR,Tubbs A,Baird MA,Davidson MW,Piel M,Alushin GM,Nussenzweig A,Steeg PS,Waterman CM

Thu Dec 01 00:00:00 EST 2016

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.

Molecular biology of the cell

Bartolini F,Andres-Delgado L,Qu X,Nik S,Ramalingam N,Kremer L,Alonso MA,Gundersen GG

Wed Jun 01 00:00:00 EDT 2016

An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.

Molecular biology of the cell

Bartolini F,Andres-Delgado L,Qu X,Nik S,Ramalingam N,Kremer L,Alonso MA,Gundersen GG

Wed Jun 01 00:00:00 EDT 2016

Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.

Nephrology (Carlton, Vic.)

Tamura H,Nakazato H,Kuraoka S,Yoneda K,Takahashi W,Endo F

Wed Jun 01 00:00:00 EDT 2016

Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.

Nephrology (Carlton, Vic.)

Tamura H,Nakazato H,Kuraoka S,Yoneda K,Takahashi W,Endo F

Wed Jun 01 00:00:00 EDT 2016

Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.

Nephrology (Carlton, Vic.)

Tamura H,Nakazato H,Kuraoka S,Yoneda K,Takahashi W,Endo F

Wed Jun 01 00:00:00 EDT 2016

Reduced INF2 expression in nephrotic syndrome is possibly related to clinical severity of steroid resistance in children.

Nephrology (Carlton, Vic.)

Tamura H,Nakazato H,Kuraoka S,Yoneda K,Takahashi W,Endo F

Wed Jun 01 00:00:00 EDT 2016

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

eLife

Wales P,Schuberth CE,Aufschnaiter R,Fels J,García-Aguilar I,Janning A,Dlugos CP,Schäfer-Herte M,Klingner C,Wälte M,Kuhlmann J,Menis E,Hockaday Kang L,Maier KC,Hou W,Russo A,Higgs HN,Pavenstädt H,Vogl T,Roth J,Qualmann B,Kessels MM,Martin DE,Mulder B,Wedlich-Söldner R

Tue Dec 06 00:00:00 EST 2016

Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

eLife

Tue Dec 06 00:00:00 EST 2016

Mechanical stimulation induces formin-dependent assembly of a perinuclear actin rim.