Immunogen sequence: GVARISDALL QLTCVSCVRA VMNSRQGIEY ILSNQGYVRQ LSQALDTSNV MVKKQVFELL AALCIYSPEG HVLTLDALDH YKTVCSQQYR FSIVMNELSG SDNVPYVVTL LSVINAVILG PEDLRARTQL RNEFIGLQLL DVLAR
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.
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Protein Aliases: HBEAG-binding protein 2 binding protein C; HBEBP2-binding protein C; inverted formin; inverted formin 2; Inverted formin-2; MGC13251
Gene Aliases: C14orf151; C14orf173; CMTDIE; FSGS5; INF2; pp9484
UniProt ID: (Human) Q27J81
Entrez Gene ID: (Human) 64423