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ING2 Polyclonal Antibody

View all (21) ING2 antibodies

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ING2 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HEK-293 cells using 11560-1-AP (ING2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ING2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human cervical cancer using 11560-1-AP (ING2 antibody) at dilution of 1:50 (under 40x lens).

ING2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human cervical cancer using 11560-1-AP (ING2 antibody) at dilution of 1:50 (under 10x lens).

ING2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 11560-1-AP (ING2 antibody) at dilution of 1:50 (under 40x lens).

ING2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 11560-1-AP (ING2 antibody) at dilution of 1:50 (under 10x lens).

ING2 Antibody in Western Blot (WB) — Human liver tissue were subjected to SDS PAGE followed by western blot with 11560-1-AP (ING2 antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours.

ING2 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 11560-1-AP (ING2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours.

ING2 Antibody in Immunoprecipitation (IP) — IP result of anti-ING2 (IP:11560-1-AP, 3ug; Detection:11560-1-AP 1:500) with HEK-293 cells lysate 1000ug.

Product Details

11560-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 5 publications 5 publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:50-1:500	-
Immunoprecipitation (IP)	0.5-4.0 µg	-
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ING2 Fusion Protein Ag2121 (1-280 aa encoded by BC030128) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.23 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

11560-1-AP is a rabbit polyclonal antibody raised against full length ING2 of human origin.

Immunogen sequence: MLGQQQQQL YSSAALLTGE RSRLLTCYVQ DYLECVESLP HDMQRNVSVL RELDNKYQET LKEIDDVYEK YKKEDDLNQK KRLQQLLQRA LINSQELGDE KIQIVTQMLE LVENRARQME LHSQCFQDPA ESERASDKAK MDSSQPERSS RRPRRQRTSE SRDLCHMANG IEDCDDQPPK EKKSKSAKKK KRSKAKQERE ASPVEFAIDP NEPTYCLCNQ VSYGEMIGCD NEQCPIEWFH FSCVSLTYKP KGKWYCPKCR GDNEKTMDKS TEKTKKDRRS R (1-280 aa encoded by BC030128)

Target Information

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Expression pattern and level of ING5 protein in normal and cancer tissues.

Oncology letters

Yang XF,Shen DF,Zhao S,Ren TR,Gao Y,Shi S,Wu JC,Sun HZ,Zheng HC

Tue Jan 01 00:00:00 EST 2019

Expression pattern and level of ING5 protein in normal and cancer tissues.

Oncology letters

Yang XF,Shen DF,Zhao S,Ren TR,Gao Y,Shi S,Wu JC,Sun HZ,Zheng HC

Tue Jan 01 00:00:00 EST 2019

A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.

Journal of molecular medicine (Berlin, Germany)

Esmaeili M,Pungsrinont T,Schaefer A,Baniahmad A

Sat Oct 01 00:00:00 EDT 2016

Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.

Molecular medicine reports

Zhao S,Yang XF,Gou WF,Lu H,Li H,Zhu ZT,Sun HZ,Zheng HC

Mon Feb 01 00:00:00 EST 2016

Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells.

Digestive diseases and sciences

Zhong J,Yang L,Liu N,Zheng J,Lin CY

Fri Nov 01 00:00:00 EDT 2013

Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation.

PloS one

Eapen SA,Netherton SJ,Sarker KP,Deng L,Chan A,Riabowol K,Bonni S

Thu Jan 10 00:00:00 EST 2013

Human family with sequence similarity 60 member A (FAM60A) protein: a new subunit of the Sin3 deacetylase complex.

Molecular & cellular proteomics : MCP

Smith KT,Sardiu ME,Martin-Brown SA,Seidel C,Mushegian A,Egidy R,Florens L,Washburn MP,Workman JL

Sat Dec 01 00:00:00 EST 2012

Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex.

Chemistry & biology

Smith KT,Martin-Brown SA,Florens L,Washburn MP,Workman JL

Fri Jan 29 00:00:00 EST 2010

Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma.

Cancer letters

Zhang HK,Pan K,Wang H,Weng DS,Song HF,Zhou J,Huang W,Li JJ,Chen MS,Xia JC

Tue Mar 18 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: ING1Lp; Inhibitor of growth 1-like protein; inhibitor of growth family, member 2; Inhibitor of growth protein 2; p32; p33ING2

Gene Aliases: 2810011M06Rik; ING1L; ING2; Ing2b; P33ING2

UniProt ID: (Human) Q9H160, (Mouse) Q9ESK4

Entrez Gene ID: (Human) 3622, (Mouse) 69260, (Rat) 290744

Molecular Function: chromatin/chromatin-binding, or -regulatory protein

transcription, DNA-templated regulation of transcription, DNA-templated male meiosis I signal transduction spermatogenesis spermatid development negative regulation of cell proliferation chromatin modification covalent chromatin modification sperm motility positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of histone deacetylation regulation of growth positive regulation of apoptotic process positive regulation of transcription, DNA-templated male germ-line stem cell asymmetric division seminiferous tubule development negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cellular senescence regulation of response to DNA damage stimulus negative regulation of apoptotic signaling pathway biological_process

Process(es)

DNA binding chromatin binding protein binding zinc ion binding protein complex binding methylated histone binding phosphatidylinositol binding metal ion binding molecular_function