Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: H1299, HepG2.
Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Eaf 4; FLJ20089; ING 2; ING 3; inhibitor of growth family, member 3; Inhibitor of growth protein 3; p47 p47 ING3; p47ING3; p47ING3 protein
Gene Aliases: Eaf4; HSPC301; ING2; ING3; MEAF4; p47ING3
UniProt ID: (Human) Q9NXR8
Entrez Gene ID: (Human) 54556
Molecular Function: chromatin/chromatin-binding, or -regulatory protein
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