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Immunogen sequence: CQGLELAREL VLAKVRALFL DALGPPAVTR EGGDPGVRRL PRRHALGGFT HRGSEPEEEE DVSQAILFPA TDASCEDKSA ARGLAQEAEE GLFRYMFRPS QHTRSRQVTS AQLWFHTGLD RQGTAASNSS EPLLGLLALS PGGPVAVPMS LGHAPPHWAV LHLATSALSL LTHPVLVLLL RCPLCTCSAR PEATPFLVAH TRTRPPSGGE RARRSTPLMS WPWSPSALRL LQRPPEEPAA HANCHRVALN ISFQELGWER WIVYPPSFIF HYCHGGCGLH IPPNLSLPVP GAPPTPAQPY SLLPGAQPCC AALPGTMRPL HVRTTSDGGY SFKYETVPNL LTQHCACI; Positive Samples: Rat testis
The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A inhibin subunit; IHA; inhibin; Inhibin alpha chain
Gene Aliases: AW555078; Inha
UniProt ID: (Rat) P17490, (Mouse) Q04997
Entrez Gene ID: (Rat) 24504, (Mouse) 16322
Molecular Function:
growth factor
signaling molecule
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