PA5-28814 targets Inhibin beta B in IF and WB applications and shows reactivity with Human samples.
The PA5-28814 immunogen is synthetic peptide corresponding to a region within amino acids 343 and 407 of Human Inhibin beta B.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
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Protein Aliases: activin AB beta polypeptide; Activin beta-B chain; beta-2; Inhibin; Inhibin beta B chain; inhibin, beta B; Inhibin, beta-2
Gene Aliases: INHBB
UniProt ID: (Human) P09529
Entrez Gene ID: (Human) 3625