DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
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Protein Aliases: Chromatin-remodeling ATPase INO80; DNA helicase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex homolog 1; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1; yeast INO80-like protein
Gene Aliases: 2310079N15Rik; 4632409L19Rik; hINO80; INO80; INO80A; INOC1; KIAA1259; RGD1310969