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Product Details
24819-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INO80 Fusion Protein Ag20309 (1217-1556 aa encoded by BC146785)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KQVTVYRLI CKGTIEERIL QRAKEKSEIQ RMVISGGNFK PDTLKPKEVV SLLLDDEELE KKLRLRQEEK RQQEETNRVK ERKRKREKYA EKKKKEDELD GKRRKEGVNL VIPFVPSADN SNLSADGDDS FISVDSAMPS PFSEISISSE LHTGSIPLDE SSSDMLVIVD DPASSAPQSR ATNSPASITG SVSDTVNGIS IQEMPAAGRG HSARSRGRPK GSGSTAKGAG KGRSRKSTAG SAAAMAGAKA GAAAASAAAY AAYGYNVSKG ISASSPLQTS LVRPAGLADF GPSSASSPLS SPLSKGNNVP GNPKNLHMTS SLAPDSLVRK QGKGTNPSGG R (1217-1556 aa encoded by BC146785)
Target Information
DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double-stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Chromatin-remodeling ATPase INO80; DNA helicase-related INO80 complex homolog 1; DNA helicase-related protein INO80; hINO80; homolog of yeast INO80; INO80 complex subunit A; INO80 homolog; putative DNA helicase INO80 complex homolog 1
Gene Aliases: hINO80; INO80; INO80A; INOC1; KIAA1259
UniProt ID: (Human) Q9ULG1
Entrez Gene ID: (Human) 54617
mitotic sister chromatid segregation
double-strand break repair via homologous recombination
double-strand break repair
chromatin remodeling
transcription, DNA-templated
positive regulation of nuclear cell cycle DNA replication
positive regulation of cell growth
DNA duplex unwinding
cellular response to UV
positive regulation of transcription from RNA polymerase II promoter
spindle assembly
cell division
UV-damage excision repair
cellular response to ionizing radiation
regulation of G1/S transition of mitotic cell cycle
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