In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Elephant, Horse, Pig (100%).
Inositol and phosphatidylinositol phosphates are important for numerous cellular processes, including neuronal survival and signal transductions from growth factors, neurotransmitters and G protein coupled receptors. INPP5J (inositol polyphosphate-5-phosphatase J), also known as phosphatidylinositol 4,5-bisphosphate 5-phosphatase A, PIPP (proline-rich inositol polyphosphate 5-phosphatase), PIB5PA or INPP5, is a 1,006 amino acid cytoplasmic protein that assists in the conversion of inositol 1,4-bisphosphate from inositol 1,4,5-trisphosphate. Expressed in lung, stomach, kidney, brain, small intestine and heart, INPP5J localizes to membrane ruffles, where it may also participate in modulating inositol and phosphatidylinositol polyphosphate-binding proteins. Encoded by a gene located on human chromosome 22, INPP5J undergoes alternative splicing to produce three isoforms.
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Protein Aliases: 5) bisphosphate 5-phosphatase; 5-bisphosphate 5-phosphatase A; A; Inositol polyphosphate 5-phosphatase J; INPP5; phosphatidylinositol (4; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A; phosphatidylinositol 4; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; PIB5PA; PIPP
Gene Aliases: INPP5; INPP5J; PIB5PA; PIPP
UniProt ID: (Human) Q15735
Entrez Gene ID: (Human) 27124