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Proteintech
INSIG1 Polyclonal Antibody
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Product Details
55282-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
300 µg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ER located; growth response protein (CL-6); Immediate-early protein CL-6; INSIG-1; INSIG-1 membrane protein; Insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405; unnamed protein product
Gene Aliases: 1810013C12Rik; Cl-6; CL6; Insig-1; INSIG1
UniProt ID: (Human) O15503, (Mouse) Q8BGI3, (Rat) Q08755
Entrez Gene ID: (Human) 3638, (Mouse) 231070, (Rat) 64194
lipid metabolic process
triglyceride metabolic process
cholesterol biosynthetic process
response to sterol depletion
steroid metabolic process
cholesterol metabolic process
negative regulation of steroid biosynthetic process
sterol biosynthetic process
SREBP signaling pathway
inner ear morphogenesis
middle ear morphogenesis
negative regulation of fat cell differentiation
negative regulation of fatty acid biosynthetic process
palate development
cranial suture morphogenesis
negative regulation of cargo loading into COPII-coated vesicle
NLS-bearing protein import into nucleus
cellular response to insulin stimulus
cellular response to sterol
SREBP-SCAP complex retention in endoplasmic reticulum
cholesterol homeostasis
negative regulation of cholesterol biosynthetic process
positive regulation of cholesterol biosynthetic process
protein maturation
negative regulation of protein exit from endoplasmic reticulum
response to estradiol
response to lipid
response to peptide hormone
response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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