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Antibody detects endogenous levels of total INSIG1.
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: INSIG-1; INSIG-1 membrane protein; Insulin-induced gene 1 protein; MGC1405
Gene Aliases: 1810013C12Rik; CL-6; CL6; Insig-1; INSIG1
UniProt ID: (Human) O15503, (Mouse) Q8BGI3
Entrez Gene ID: (Human) 3638, (Mouse) 231070
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