Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling
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Protein Aliases: homolog of inturned; INT; INTU; Inturned planar cell polarity effector homolog; KIAA1284; PDZ domain containing 6; PDZ domain-containing protein 6; PDZD6; PDZK6; Protein inturned
Gene Aliases: 9230116I04Rik; 9430087H23Rik; INT; INTU; KIAA1284; mKIAA1284; PDZD6; PDZK6