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Proteintech
INTU Polyclonal Antibody
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Product Details
24914-1-AP
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INTU Fusion Protein Ag19313 (1-354 aa encoded by BC130611)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASVASCDS RPSSDELPGD PSSQEEDEDY DFEDRVSDSG SYSSASSDYD DLEPEWLDSV QKNGELFYLE LSEDEEESLL PETPTVNHVR FSENEIIIED DYKERKKYEP KLKQFTKILR RKRLLPKRCN KKNSNDNGPV SILKHQSNQK TGVIVQQRYK DVNVYVNPKK LTVIKAKEQL KLLEVLVGII HQTKWSWRRT GKQGDGERLV VHGLLPGGSA MKSGQVLIGD VLVAVNDVDV TTENIERVLS CIPGPMQVKL TFENAYDVKR ETSHPRQKKT QSNTSDLVKL LWGEEVEGIQ QSGLNTPHII MYLTLQLDSE TSKEEQEILY HYPMSEASQK LKSVRGIFLT LCDML (1-354 aa encoded by BC130611)
Target Information
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ciliogenesis and planar polarity effector 4; ciliogenesis and planar polarity effector complex subunit 4; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned; unnamed protein product
Gene Aliases: 9230116I04Rik; 9430087H23Rik; CPLANE4; INT; INTU; KIAA1284; mKIAA1284; OFD17; PDZD6; PDZK6; SRTD20
UniProt ID: (Human) Q9ULD6, (Mouse) Q059U7
Entrez Gene ID: (Human) 27152, (Mouse) 380614
establishment of planar polarity
smoothened signaling pathway
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
vesicle-mediated transport
spinal cord dorsal/ventral patterning
neural tube development
cell projection organization
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
protein localization to organelle
intraciliary transport
embryonic digit morphogenesis
tongue morphogenesis
motile cilium assembly
positive regulation of smoothened signaling pathway
cell division
negative regulation of cell division
palate development
limb development
cilium morphogenesis
regulation of cilium assembly
non-motile cilium assembly
multicellular organism development
cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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