Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Abnova
INTU Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
H00027152-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
INTU (ENSP00000296461, 1 a.a. approximately 408 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MASVASCDSR PSSDELPGDP SSQEEDEDYD FEDRVSDSGS YSSASSDYDD LEPEWLDSVQ KNGELFYLEL SEDEEESLLP ETPTVNHVRF SENEIIIEDD YKERKKYEPK LKQFTKILRR KRLLPKRCNK KNSNDNGPVS ILKHQSNQKT GVIVQQRYKD VNVYVNPKKL TVIKAKEQLK LLEVLVGIIH QTKWSWRRTG KQGDGERLVV HGLLPGGSAM KSGQVLIGDV LVAVNDVDVT TENIERVLSC IPGPMQVKLT FENAYDVKRE TSHPRQKKTQ SNTSDLVKLL WGEEVEGIQQ SGLNTPHIIM YLTLQLDSET SKEEQEILYH YPMSEASQKL KSVRGIFLTL CDMLENVTGT QVTSSSLLLN GKQIHVAYWK ESDKLLLIGL PAEEIELPSS AHTHGERN
Target Information
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: homolog of inturned; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned
Gene Aliases: INT; INTU; KIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6
Entrez Gene ID: (Human) 27152
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
spinal cord dorsal/ventral patterning
neural tube development
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
cilium assembly
embryonic digit morphogenesis
positive regulation of smoothened signaling pathway
negative regulation of cell division
limb development
motile primary cilium assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support