This target displays homology in the following species: Dog: 79%; Human: 100%
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of inturned; INT; Inturned planar cell polarity effector homolog; inturned planar cell polarity protein; PDZ domain containing 6; PDZ domain-containing protein 6; PDZD6; PDZK6; Protein inturned
Gene Aliases: INT; INTU; KIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6