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Product Details
PA5-70787
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1.0 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
synthetic peptide directed towards the C-terminal region of human INTU |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5-1.0 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2690064 |
Product Specific Information
This target displays homology in the following species: Dog: 79%; Human: 100%
Target Information
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homolog of inturned; Inturned planar cell polarity effector homolog; PDZ domain containing 6; PDZ domain-containing protein 6; Protein inturned
Gene Aliases: INT; INTU; KIAA1284; PDZD6; PDZK6
UniProt ID: (Human) Q9ULD6
Entrez Gene ID: (Human) 27152
nervous system development
regulation of smoothened signaling pathway
negative regulation of keratinocyte proliferation
spinal cord dorsal/ventral patterning
neural tube development
keratinocyte differentiation
regulation of ossification
hair follicle morphogenesis
cilium assembly
embryonic digit morphogenesis
positive regulation of smoothened signaling pathway
negative regulation of cell division
limb development
motile primary cilium assembly
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