This antibody is a rabbit polyclonal antibody raised against part of N-terminus of human INVS. The calculated molecular weight of INVS is 80 kDa, but the modified INVS protein is about 100-110 kDa.
This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Inversin; Inversion of embryo turning homolog; inversion of embryo turning protein; inversion of embryonic turning; nephrocystin 2; Nephrocystin-2
Gene Aliases: INV; INVS; NPH2; NPHP2; RGD1563359
UniProt ID: (Human) Q9Y283