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Invitrogen
IP3 Receptor 1 Polyclonal Antibody
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FIGURE: 1 / 29
IP3 Receptor 1 Antibody (PA1-901) in ICC/IF
Immunofluorescence analysis of IP3 Receptor I was done on 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with IP3 Receptor I Rabbit Polyclonal Antibody (Product # PA1-901) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at... View More
Product Details
PA1-901
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
C. elegans,
Hamster,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic Peptide: N(1829) K K K D D E V D R D A P S R K K A K E(1848)
Conjugate
Form
Liquid
Concentration
1.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-901 detects inositol 1,4,5-trisphosphate receptor type-I (IP3R-I) from canine, mouse and rat tissues.
PA1-901 has been successfully used in Western blot, immunohistochemistry, immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~240 kDa protein representing IP3R-I from rat and mouse brain extract. Immunohistochemical staining of IP3R-I in rat cerebellum with PA1-901 results in staining of Purkinje cells.
PA1-901 immunizing peptide corresponds to amino acid residues 1829-1848 from human IP3R-I. This sequence is completely conserved in human, mouse, and rat IP3R-I. PA1-901 immunizing peptide (Cat. # PEP-019) is available for use in neutralization and control experiments.
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
Gene Aliases: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Dog) 476548, (Human) 3708, (Mouse) 16438, (Rat) 25262
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
protein binding
calcium ion transmembrane transporter activity
calcium-release channel activity
calcium channel inhibitor activity
phosphatidylinositol binding
ion channel activity
calcium channel activity
protein C-terminus binding
protein phosphatase binding
protein complex binding
ligand-gated ion channel
response to hypoxia
calcium ion transport
signal transduction
post-embryonic development
regulation of autophagy
platelet activation
endoplasmic reticulum calcium ion homeostasis
epithelial fluid transport
inositol phosphate-mediated signaling
regulation of insulin secretion
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of cardiac conduction
transport
ion transport
apoptotic process
positive regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
transmembrane transport
calcium ion transmembrane transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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