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Invitrogen
IP3 Receptor 1 Polyclonal Antibody
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FIGURE: 1 / 2
IP3 Receptor 1 Antibody (PA3-901A) in WB
Frontiers in cell and developmental biology 2023 -
FIGURE 1 TNBC cells display frequent IP3-linked Ca 2+ oscillations. (A) Representative traces of cytosolic Ca 2+ measurements (expressed as FURA-2 340/380 nm ratio, R) in MCF10A, MDA-MB-231 CTRL and MDA-MB-231 MCU-KO cells upon acute stimulation (arrows) by FCS (2%) or ATP (100 uM). Bars represent the corresponding quantification of DeltaR upon FCS or ATP stimulation, as indicated. n = 74-88 cells from 3 in... View More
Product Details
PA3-901A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum, PBS
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-901A detects inositol 1,4,5-triphosphate receptor type-I (IP3R-I) from mouse, human and rat tissues.
PA3-901A has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~240-260 kDa protein representing IP3R-I from rat and mouse brain extract. PA3-901A is a remanufactured lot of PA3-901 which has previously been used in Western blot, immunoprecipitation and immunohistochemistry procedures.
The PA3-901A immunogen is a synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I. This sequence is 100% conserved in human, mouse, and rat IP3R-I protein. This peptide (Cat. # PEP-019) is available for use in neutralization and control experiments.
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:
Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3
Gene Aliases: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994
Entrez Gene ID: (Human) 3708, (Mouse) 16438, (Rat) 25262
nucleotide binding
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
calcium ion transmembrane transporter activity
calcium-release channel activity
calcium channel inhibitor activity
protein domain specific binding
phosphatidylinositol binding
protein homodimerization activity
metal ion binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
protein C-terminus binding
protein phosphatase binding
protein complex binding
ligand-gated ion channel
cell morphogenesis
response to hypoxia
ion transport
calcium ion transport
apoptotic process
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
single fertilization
post-embryonic development
regulation of autophagy
calcium-mediated signaling
positive regulation of insulin secretion
endoplasmic reticulum calcium ion homeostasis
ion transmembrane transport
calcium ion transmembrane import into mitochondrion
epithelial fluid transport
positive regulation of apoptotic process
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of cytosolic calcium ion concentration
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
regulation of postsynaptic cytosolic calcium ion concentration
release of sequestered calcium ion into cytosol by endoplasmic reticulum
ligand-gated ion channel signaling pathway
transport
positive regulation of cytosolic calcium ion concentration
inositol phosphate-mediated signaling
positive regulation of calcium ion transport
cellular response to cAMP
negative regulation of neuron death
cellular response to hypoxia
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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