|Western Blot (WB)||Assay dependent|
|Western Blot (WB)||See 1 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human, Mouse, Rat|
|Published species reactivity||Rat Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I.|
|Storage buffer||whole serum diluted in PBS|
|Contains||0.05% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA3-901A detects inositol 1,4,5-triphosphate receptor type-I (IP3R-I) from mouse, human and rat tissues.
PA3-901A has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~240-260 kDa protein representing IP3R-I from rat and mouse brain extract. PA3-901A is a remanufactured lot of PA3-901 which has previously been used in Western blot, immunoprecipitation and immunohistochemistry procedures.
The PA3-901A immunogen is a synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I. This sequence is 100% conserved in human, mouse, and rat IP3R-I protein. This peptide (Cat. # PEP-019) is available for use in neutralization and control experiments.
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: -Triphosphate Receptor Type I; 4; 5; Inositol 1; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; InsP3R type I; insP3R1; InsP>3<R type I; IP-3-R; IP3 receptor; IP3 receptor isoform 1; IP3R 1; opisthotonus; Protein PCD-6; protein phosphatase 1, regulatory subunit 94; Purkinje cell protein 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene Aliases: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.