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IP3R 1 Polyclonal Antibody
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FIGURE: 1 / 15
IP3R 1 Antibody (OST00428W-100UL) in IHC (P)
IHC-P on paraffin sections of rat cerebellum. The animal was perfused using Autoperfuser at a pressure of 110 mmHg with 300 mL 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructi... View More
Product Details
OST00428W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 700-750 of human IP3R1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: INSP3R1.
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor type 1; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; IP3 receptor; IP3 receptor isoform 1; IP3R 1; protein phosphatase 1, regulatory subunit 94; SI-SIII-SIIA; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor; unnamed protein product
Gene Aliases: ACV; CLA4; INSP3R1; IP3R; IP3R1; ITPR1; PPP1R94; SCA15; SCA16; SCA29
UniProt ID: (Human) Q14643
Entrez Gene ID: (Human) 3708
nucleotide binding
ion channel activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
calcium channel activity
calcium ion binding
protein binding
ATP binding
calcium ion transmembrane transporter activity
calcium-release channel activity
calcium channel inhibitor activity
protein domain specific binding
phosphatidylinositol binding
protein homodimerization activity
metal ion binding
inositol 1,4,5 trisphosphate binding
inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels
cell morphogenesis
response to hypoxia
ion transport
calcium ion transport
apoptotic process
signal transduction
phospholipase C-activating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
single fertilization
post-embryonic development
regulation of autophagy
calcium-mediated signaling
positive regulation of insulin secretion
endoplasmic reticulum calcium ion homeostasis
ion transmembrane transport
calcium ion transmembrane import into mitochondrion
epithelial fluid transport
positive regulation of apoptotic process
negative regulation of calcium-mediated signaling
voluntary musculoskeletal movement
release of sequestered calcium ion into cytosol
protein homotetramerization
regulation of cytosolic calcium ion concentration
transmembrane transport
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
calcium ion transmembrane transport
regulation of postsynaptic cytosolic calcium ion concentration
release of sequestered calcium ion into cytosol by endoplasmic reticulum
ligand-gated ion channel signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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