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Proteintech
IP6K2 Polyclonal Antibody
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Product Details
13155-1-AP
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IP6K2 Fusion Protein Ag3786 (1-350 aa encoded by BC019694)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes the others except the 8 kDa isoform of IP6K2.
Immunogen sequence: MSPAFRAMD VEPRAKGVLL EPFVHQVGGH SCVLRFNETT LCKPLVPREH QFYETLPAEM RKFTPQYKGV VSVRFEEDED RNLCLIAYPL KGDHGIVDIV DNSDCEPKSK LLRWTTNKKH HVLETEKTPK DWVRQHRKEE KMKSHKLEEE FEWLKKSEVL YYTVEKKGNI SSQLKHYNPW SMKCHQQQLQ RMKENAKHRN QYKFILLENL TSRYEVPCVL DLKMGTRQHG DDASEEKAAN QIRKCQQSTS AVIGVRVCGM QVYQAGSGQL MFMNKYHGRK LSVQGFKEAL FQFFHNGRYL RRELLGPVLK KLTELKAVLE RQESYRFYSS SLLVIYDGKE RPEVVLDSDA E (1-350 aa encoded by BC019694)
Target Information
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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