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Invitrogen
IP6K2 Polyclonal Antibody
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FIGURE: 1 / 1
IP6K2 Antibody (PA5-49476) in WB
Western blot analysis of IP6K2 in Mouse brain lysate. Samples were incubated with IP6K2 polyclonal antibody (Product # PA5-49476) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 49 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-49476
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 226-258 amino acids from the Central region of human IP6K2.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; Inositol hexakisphosphate kinase 2; inositol hexaphosphate kinase 2; inositol-hexakisphosphate kinase; InsP6 kinase 2; IP6 Kinase; MIP6K2; P(i)-uptake stimulator; pi uptake stimulator; PiUS; similar to Homo sapiens mammalian inositol hexakisphosphate kinase 2 (IP6K2) mRNA with GenBank Accession Number AF177145; unnamed protein product
Gene Aliases: 1500005N04Rik; AW050208; IHPK2; InsP6K2; IP6K2; PIUS; TCCCIA00113
UniProt ID: (Human) Q9UHH9, (Mouse) Q80V72
Entrez Gene ID: (Human) 51447, (Mouse) 76500
nucleotide binding
inositol-1,3,4,5,6-pentakisphosphate kinase activity
inositol hexakisphosphate kinase activity
inositol heptakisphosphate kinase activity
inositol hexakisphosphate 5-kinase activity
protein binding
ATP binding
kinase activity
transferase activity
inositol 5-diphosphate pentakisphosphate 5-kinase activity
inositol diphosphate tetrakisphosphate kinase activity
flavonoid binding
inositol-1,4,5-trisphosphate 3-kinase activity
inositol hexakisphosphate 1-kinase activity
inositol hexakisphosphate 3-kinase activity
kinase
lipid metabolic process
negative regulation of cell growth
inositol phosphate biosynthetic process
positive regulation of apoptotic process
inositol phosphate metabolic process
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
protein stabilization
organophosphate biosynthetic process
cellular response to flavonoid
phosphate ion transport
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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