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Invitrogen
IPO5 Polyclonal Antibody
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FIGURE: 1 / 3
IPO5 Antibody (PA5-78567) in IHC (P)
IPO5 Polyclonal Antibody detects IPO5 protein at nucleus on rat hind brain by immunohistochemical analysis. Sample: Paraffin-embedded rat hind brain. IPO5 Polyclonal Antibody (Product # PA5-78567) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78567
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human IPO5. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.58 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted Reactivity: Human (100%), Xenopus laevis (96%), Pig (98%), Chimpanzee (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Imp5; importin 5; importin beta-3 subunit; Importin subunit beta-3; Importin-5; IPO 5; karyopherin (importin) beta 3; Karyopherin beta 3; Karyopherin beta-3; MGC2068; RAN binding protein 5; Ran-binding protein 5; Ran_GTP binding protein 5; RanBP 5; RanBP5
Gene Aliases: 1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; imp5; IPO5; KPNB3; Pse1; RANBP5
UniProt ID: (Human) O00410, (Mouse) Q8BKC5
Entrez Gene ID: (Human) 3843, (Rat) 306182, (Mouse) 70572
protein import into nucleus, docking
protein import into nucleus, translocation
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
viral process
negative regulation of GTPase activity
positive regulation of protein import into nucleus
cellular response to amino acid stimulus
intracellular protein transport
transport
protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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