Predicted Reactivity: Human (100%), Xenopus laevis (96%), Pig (98%), Chimpanzee (98%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IMB3; Imp5; importin 5; importin beta-3 subunit; Importin subunit beta-3; Importin-5; karyopherin (importin) beta 3; Karyopherin beta-3; KPNB3; Pse1; RAN binding protein 5; Ran-binding protein 5; Ran_GTP binding protein 5; RANBP5
Gene Aliases: 1110011C18Rik; 5730478E03Rik; AA409333; C76941; IMB3; imp5; IPO5; KPNB3; Pse1; RANBP5