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Invitrogen
IQGAP3 Polyclonal Antibody
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Product Details
PA5-101817
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IQGAP3(Accession Q86VI3), corresponding to amino acid residues I106-P156.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total IQGAP3.
Target Information
IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IQGA3; IQGAP3; MGC10170; Ras GTPase-activating-like protein IQGAP3; unnamed protein product
Gene Aliases: AI593484; D030034H08; IQGAP3
UniProt ID: (Human) Q86VI3
Entrez Gene ID: (Human) 128239, (Mouse) 404710, (Rat) 310621
G1/S transition of mitotic cell cycle
Ras protein signal transduction
regulation of cell size
gene expression
positive regulation of gene expression
negative regulation of gene expression
mammary gland epithelial cell proliferation
positive regulation of mammary gland epithelial cell proliferation
positive regulation of MAPK cascade
ERK1 and ERK2 cascade
mitotic actomyosin contractile ring assembly actin filament organization
activation of MAPK activity
positive regulation of protein phosphorylation
cellular response to organic substance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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