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Invitrogen
IQSEC1 Polyclonal Antibody
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FIGURE: 1 / 1
IQSEC1 Antibody (PA5-95835) in WB
Western blot analysis of IQSEC1 in extracts of various cell lines. Samples were incubated with IQSEC1 Polyclonal antibody (Product # PA5-95835) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5 min.
Product Details
PA5-95835
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_0556843)
Conjugate
Form
Liquid
Concentration
1.25 mg/mL
Amount
125 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: mouse brain, rat brain
Immunogen sequence: SFEGPEKVHS SYFEGKQVSV TNDGSQLGAL VSPECGDLSE PTTLKSPAPS SDFADAITEL EDAFSRQVKS LAESIDDALN CRSLHTEEAP ALDAARARDT EPQTALHGMD HRKLDEMTAS YSDVTLYIDE EELSPPLPLS QAGDRPSSTE SDLRLRAGGA APDYWALAHK EDKADTDTSC RSTPSLERQE QRLRVEHLPL L
Target Information
ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1
Gene Aliases: AW561907; BC026481; BRAG2; cI-43; D6Ertd349e; Iqsec1; Kiaa0763
UniProt ID: (Mouse) Q8R0S2
Entrez Gene ID: (Mouse) 232227, (Rat) 686590
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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