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Keep as concentrated solution.
Predicted reactivity: Mouse (90%), Rat (92%), Bovine (89%).
Positive Control: HepG2, PC-12, Rat-2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase 1 antibody; interleukin-1 receptor-associated kinase-1; IRAK; IRAK antibody; IRAK-1; IRAK-1 antibody; IRAK1 antibody; mPLK; pelle antibody; Pelle homolog; Pelle homolog antibody; Pelle-like protein kinase
Gene Aliases: AA408924; Il1rak; IRAK; IRAK-1; IRAK1; IRAK1-S; mPLK; pelle; Plpk; RGD1563841
UniProt ID: (Human) P51617, (Mouse) Q62406
Entrez Gene ID: (Human) 3654, (Mouse) 16179, (Rat) 363520
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