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Invitrogen
IREB2 Polyclonal Antibody
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Product Details
PA5-86058
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human IREB2 aa 17-301
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures. IRP2 is regulated by iron-mediated proteolysis. Hypoxia is important for normal tissue physiology as well as being a component of several pathophysiological conditions, including heart and cerebrovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also plays a role during hypoxia (low oxygen).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23381; IRE-BP 2; Iron regulatory protein 2; iron-regulatory protein 2; iron-responsive element binding protein 2; Iron-responsive element-binding protein 2; IRP2
Gene Aliases: ACO3; D9Ertd85e; IREB2; IRP2; IRP2AD
UniProt ID: (Human) P48200, (Rat) Q62751, (Mouse) Q811J3
Entrez Gene ID: (Human) 3658, (Rat) 64831, (Mouse) 64602
iron ion transport
cellular iron ion homeostasis
metabolic process
negative regulation of translation
regulation of translation
protoporphyrinogen IX biosynthetic process
aging
post-embryonic development
response to iron(II) ion
regulation of gene expression
osteoclast differentiation
response to retinoic acid
erythrocyte homeostasis
intestinal absorption
iron ion homeostasis
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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