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Invitrogen
IRF1 Polyclonal Antibody
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Product Details
PA5-50512
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human interferon regulatory factor 1
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total IRF1 protein.
Target Information
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. Diseases associated with IRF1 include gastric cancer, somatic and lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Interferon regulatory factor 1; interferon regulatory factor 1 isoform +I9; interferon regulatory factor 1 isoform d78; interferon regulatory factor 1 isoform delta4; interferon regulatory factor 1 isoform delta7; IRF-1
Gene Aliases: AU020929; IRF-1; IRF1; MAR
UniProt ID: (Human) P10914, (Mouse) P15314
Entrez Gene ID: (Human) 3659, (Mouse) 16362
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
regulatory region DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
winged helix/forkhead transcription factor
regulation of adaptive immune response
transcription from RNA polymerase II promoter
apoptotic process
cell cycle arrest
blood coagulation
negative regulation of cell proliferation
positive regulation of type I interferon production
positive regulation of interferon-beta production
regulation of MyD88-dependent toll-like receptor signaling pathway
cellular response to interferon-beta
CD8-positive, alpha-beta T cell differentiation
positive regulation of interleukin-12 biosynthetic process
regulation of innate immune response
negative regulation of regulatory T cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of cell cycle
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
cellular response to mechanical stimulus
regulation of CD8-positive, alpha-beta T cell proliferation
immune system process
transcription, DNA-templated
regulation of transcription, DNA-templated
I-kappaB kinase/NF-kappaB signaling
regulation of gene expression
positive regulation of cell death
positive regulation of natural killer cell differentiation
negative regulation of tyrosine phosphorylation of Stat1 protein
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
response to growth hormone
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to peptide hormone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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