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Proteintech
IRF7 Polyclonal Antibody
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Product Details
22392-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fish,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IRF7 Fusion Protein Ag18059 (168-516 aa encoded by BC136555)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against the C-terminal 349 amino acid residues of human IRF7 D. The molecular weight of non-phosphorylated IRF7 is 44 kDa while phosphorylated IRF7 is 80-90 kDa.
Immunogen sequence: PGPFLAHTH AGLQAPGPLP APAGDKGDLL LQAVQQSCLA DHLLTASWGA DPVPTKAPGE GQEGLPLTGA CAGGPGLPAG ELYGWAVETT PSPGPQPAAL TTGEAAAPES PHQAEPYLSP SPSACTAVQE PSPGALDVTI MYKGRTVLQK VVGHPSCTFL YGPPDPAVRA TDPQQVAFPS PAELPDQKQL RYTEELLRHV APGLHLELRG PQLWARRMGK CKVYWEVGGP PGSASPSTPA CLLPRNCDTP IFDFRVFFQE LVEFRARQRR GSPRYTIYLG FGQDLSAGRP KEKSLVLVKL EPWLCRVHLE GTQREGVSSL DSSSLSLCLS SANSLYDDIE CFLMELEQPA (168-516 aa encoded by BC136555)
Target Information
Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Interferon regulatory factor 7; interferon regulatory factor-7H; IRF-7
Gene Aliases: IMD39; IRF-7H; IRF7; IRF7A; IRF7B; IRF7C; IRF7H
UniProt ID: (Human) Q92985, (Mouse) P70434
Entrez Gene ID: (Human) 3665, (Mouse) 54123
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
protein binding
regulatory region DNA binding
transcription factor activity, sequence-specific DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of adaptive immune response
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
response to virus
immunoglobulin mediated immune response
establishment of viral latency
regulation of type I interferon production
positive regulation of type I interferon production
interferon-alpha production
interferon-beta production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
regulation of MyD88-dependent toll-like receptor signaling pathway
regulation of MyD88-independent toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
MDA-5 signaling pathway
innate immune response
type I interferon biosynthetic process
regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of immune response
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
negative regulation of macrophage apoptotic process
immune system process
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
regulation of innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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