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IRF7 Polyclonal Antibody

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Antibody Testing Data (6)

IRF7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

IRF7 Antibody (22392-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 22392-1-AP ( IRF7 Antibody) at dilution of 1:50 (under 40x lens).

IRF7 Antibody in Immunoprecipitation (IP)

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Product Details

22392-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fish, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IRF7 Fusion Protein Ag18059 (168-516 aa encoded by BC136555)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against the C-terminal 349 amino acid residues of human IRF7 D. The molecular weight of non-phosphorylated IRF7 is 44 kDa while phosphorylated IRF7 is 80-90 kDa.

Immunogen sequence: PGPFLAHTH AGLQAPGPLP APAGDKGDLL LQAVQQSCLA DHLLTASWGA DPVPTKAPGE GQEGLPLTGA CAGGPGLPAG ELYGWAVETT PSPGPQPAAL TTGEAAAPES PHQAEPYLSP SPSACTAVQE PSPGALDVTI MYKGRTVLQK VVGHPSCTFL YGPPDPAVRA TDPQQVAFPS PAELPDQKQL RYTEELLRHV APGLHLELRG PQLWARRMGK CKVYWEVGGP PGSASPSTPA CLLPRNCDTP IFDFRVFFQE LVEFRARQRR GSPRYTIYLG FGQDLSAGRP KEKSLVLVKL EPWLCRVHLE GTQREGVSSL DSSSLSLCLS SANSLYDDIE CFLMELEQPA (168-516 aa encoded by BC136555)

Target Information

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma.

Frontiers in oncology

Pan H,Lu W,Zhang M,Liu C

Tue May 16 00:00:00 EDT 2023

NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.

International immunopharmacology

Chen L,Dai M,Zuo W,Dai Y,Yang Q,Yu S,Huang M,Liu H

Wed Feb 01 00:00:00 EST 2023

NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.

International immunopharmacology

Chen L,Dai M,Zuo W,Dai Y,Yang Q,Yu S,Huang M,Liu H

Wed Feb 01 00:00:00 EST 2023

NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.

International immunopharmacology

Chen L,Dai M,Zuo W,Dai Y,Yang Q,Yu S,Huang M,Liu H

Wed Feb 01 00:00:00 EST 2023

Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses.

Cell chemical biology

Maarifi G,Martin MF,Zebboudj A,Boulay A,Nouaux P,Fernandez J,Lagisquet J,Garcin D,Gaudin R,Arhel NJ,Nisole S

Thu Jul 21 00:00:00 EDT 2022

Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.

Journal of immunology (Baltimore, Md. : 1950)

Cao W,Guo Y,Cheng Z,Xu G,Zuo Q,Nie L,Huang Y,Liu S,Zhu Y

Tue Jun 01 00:00:00 EDT 2021

Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Cai Y,Xu B,Zhou F,Wu J,Li S,Zheng Q,Li Y,Li X,Gao F,Dong S,Liu R

Thu Apr 01 00:00:00 EDT 2021

TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.

Molecular medicine reports

Liu X,Wang X,Liu N,Zhu K,Zhang S,Duan X,Huang Y,Jin Z,Jaypaul H,Wu Y,Chen H

Wed Apr 01 00:00:00 EDT 2020

pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection.

Fish & shellfish immunology

Guan XL,Zhang BC,Sun L

Mon Apr 01 00:00:00 EDT 2019

pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection.

Fish & shellfish immunology

Guan XL,Zhang BC,Sun L

Mon Apr 01 00:00:00 EDT 2019

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.

Cancer medicine

Lyu XM,Zhu XW,Zhao M,Zuo XB,Huang ZX,Liu X,Jiang T,Yang XX,Li X,Long XB,Wang JG,Li JB,Han MY,Wang S,Liu TF,Zhang B,Sun T,Cheng Z,Qiu MC,Dong L,Zheng L,Zhang LC,Wang JH,Wei GG,Yao K,Wang Q,Zheng HF,Li X

Wed Aug 01 00:00:00 EDT 2018

A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.

Cancer medicine

Wed Aug 01 00:00:00 EDT 2018

Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Journal of immunology (Baltimore, Md. : 1950)

Xia Z,Xu G,Yang X,Peng N,Zuo Q,Zhu S,Hao H,Liu S,Zhu Y

Mon May 01 00:00:00 EDT 2017

Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Journal of immunology (Baltimore, Md. : 1950)

Xia Z,Xu G,Yang X,Peng N,Zuo Q,Zhu S,Hao H,Liu S,Zhu Y

Mon May 01 00:00:00 EDT 2017

Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle.

Journal of veterinary science

Weng XG,Song QJ,Wu Q,Liu MC,Wang ML,Wang JF

Thu Sep 22 00:00:00 EDT 2016

Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle.

Journal of veterinary science

Weng XG,Song QJ,Wu Q,Liu MC,Wang ML,Wang JF

Thu Sep 22 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: Interferon regulatory factor 7; interferon regulatory factor-7H; IRF-7

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Gene Aliases: IMD39; IRF-7H; IRF7; IRF7A; IRF7B; IRF7C; IRF7H

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UniProt ID: (Human) Q92985, (Mouse) P70434

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Entrez Gene ID: (Human) 3665, (Mouse) 54123

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Function(s)

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding regulatory region DNA binding transcription factor activity, sequence-specific DNA binding winged helix/forkhead transcription factor

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of adaptive immune response transcription from RNA polymerase II promoter cellular response to DNA damage stimulus response to virus immunoglobulin mediated immune response establishment of viral latency regulation of type I interferon production positive regulation of type I interferon production interferon-alpha production interferon-beta production positive regulation of interferon-alpha production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway regulation of MyD88-independent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway innate immune response type I interferon biosynthetic process regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway positive regulation of type I interferon-mediated signaling pathway negative regulation of macrophage apoptotic process immune system process transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of innate immune response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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IRF7 Polyclonal Antibody

IRF7 Antibody (22392-1-AP) in IHC (P)

Product Details

22392-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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